Jan A Burger Selected Research

Lymphocytosis

9/2023	Chronic Lymphocytic Leukemia: Disease Biology.
1/2019	Characterizing the kinetics of lymphocytosis in patients with chronic lymphocytic leukemia treated with single-agent ibrutinib.
1/2018	Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia.
7/2015	Trisomy 12 is associated with an abbreviated redistribution lymphocytosis during treatment with the BTK inhibitor ibrutinib in patients with chronic lymphocytic leukaemia.
3/2014	Bruton's tyrosine kinase (BTK) inhibitors in clinical trials.
11/2013	Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765).
1/2013	The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells.
2/2012	The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo.
9/2011	The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia.

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Jan A Burger Research Topics

Disease

109	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 03/2024 - 03/2002
41	Neoplasms (Cancer) 04/2024 - 11/2003
16	Leukemia 09/2023 - 03/2002
10	Disease Progression 01/2023 - 01/2012
10	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 01/2021 - 05/2009
9	Lymphocytosis 09/2023 - 09/2011
7	Hemorrhage 01/2023 - 12/2015
6	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 09/2023 - 08/2013
6	Diarrhea 12/2019 - 12/2015
5	Neutropenia 03/2024 - 12/2015
5	Infections 03/2024 - 01/2017
5	Fatigue 12/2019 - 12/2015
5	Lymphoma (Lymphomas) 11/2019 - 12/2013
4	Hypertension (High Blood Pressure) 01/2023 - 10/2018
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 04/2014
4	Waldenstrom Macroglobulinemia (Macroglobulinemia) 01/2021 - 03/2014
4	Atrial Fibrillation 12/2019 - 10/2017
4	Residual Neoplasm 11/2019 - 05/2007
4	Cytopenia 03/2017 - 09/2011
4	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 05/2015 - 11/2006
3	Philadelphia Chromosome 01/2021 - 08/2013
3	Non-Hodgkin Lymphoma (Lymphosarcoma) 11/2019 - 01/2018
3	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2017 - 12/2015
2	Thrombocytopenia (Thrombopenia) 03/2024 - 01/2018
2	Trisomy (Trisomies) 01/2022 - 07/2015
2	Nausea 12/2019 - 12/2015
2	Acute Promyelocytic Leukemia 06/2018 - 05/2015
2	Anemia 01/2018 - 12/2015
2	Lymphadenopathy 12/2014 - 03/2012
2	B-Cell Lymphoma (Lymphoma, B Cell) 02/2014 - 01/2012
2	Lung Neoplasms (Lung Cancer) 04/2012 - 04/2011
2	Neoplasm Metastasis (Metastasis) 04/2011 - 04/2009
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 06/2005 - 11/2003
1	Marginal Zone B-Cell Lymphoma (MALT Lymphoma) 09/2023
1	Chronic Renal Insufficiency 01/2023
1	Heart Diseases (Heart Disease) 01/2023
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2023
1	Membranous Glomerulonephritis (Membranous Nephropathy) 01/2023
1	Chromosome Aberrations (Chromosome Abnormalities) 01/2022

Drug/Important Bio-Agent (IBA)

63	ibrutinibIBA 01/2023 - 02/2012
31	Agammaglobulinaemia Tyrosine KinaseIBA 09/2023 - 02/2012
14	Phosphotransferases (Kinase)IBA 09/2023 - 09/2009
12	Chemokine ReceptorsIBA 09/2023 - 03/2002
12	Rituximab (Mabthera)FDA Link 12/2019 - 02/2013
8	Chlorambucil (Leukeran)FDA Link 01/2023 - 07/2015
8	Lenalidomide (CC 5013)FDA Link 01/2019 - 09/2011
7	idelalisibIBA 01/2019 - 09/2011
7	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2018 - 05/2009
5	fludarabineIBA 11/2019 - 08/2010
5	Cyclophosphamide (Cytoxan)FDA LinkGeneric 11/2019 - 05/2015
5	ChemokinesIBA 01/2018 - 03/2002
5	IntegrinsIBA 01/2018 - 11/2003
4	venetoclaxIBA 03/2024 - 10/2018
4	Proteins (Proteins, Gene)FDA Link 09/2023 - 12/2015
4	LigandsIBA 01/2018 - 11/2007
3	obinutuzumabIBA 01/2020 - 07/2015
3	Monoclonal AntibodiesIBA 11/2019 - 10/2015
3	Tyrosine Kinase InhibitorsIBA 12/2013 - 09/2009
3	Imatinib Mesylate (Gleevec)FDA Link 08/2013 - 11/2006
2	zanubrutinibIBA 01/2022 - 12/2019
2	Apoptosis Regulatory ProteinsIBA 01/2021 - 01/2011
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 12/2015
2	plerixafor FDA Link 12/2019 - 04/2011
2	umbralisibIBA 11/2019 - 02/2019
2	ublituximabIBA 11/2019 - 02/2019
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 11/2019 - 07/2015
2	B-Cell Antigen Receptors (B Cell Antigen Receptors)IBA 11/2019 - 07/2009
2	4- (cyclopropylamino)- 2- ((4- (4- (ethylsulfonyl)piperazin- 1- yl)phenyl)amino)pyrimidine- 5- carboxamideIBA 01/2019 - 05/2017
2	Janus Kinase InhibitorsIBA 01/2019 - 05/2017
2	AnticoagulantsIBA 01/2019 - 01/2017
2	AntigensIBA 01/2019 - 12/2013
2	Immunoglobulin D (IgD)IBA 01/2019 - 01/2016
2	Immunoglobulin M (IgM)IBA 01/2019 - 01/2016
2	ofatumumab FDA Link 11/2018 - 01/2016
2	Arsenic Trioxide (Trisenox)FDA Link 06/2018 - 05/2015
2	Protein Isoforms (Isoforms)IBA 01/2018 - 05/2009
2	Integrin alpha4beta1 (VLA-4)IBA 01/2018 - 05/2009
2	Vincristine (Oncovin)FDA LinkGeneric 02/2016 - 12/2015
2	Chemokine CCL3IBA 01/2016 - 02/2011
2	Syk KinaseIBA 01/2016 - 07/2009
2	Dasatinib (BMS 354825)FDA Link 12/2015 - 08/2013
2	Bendamustine Hydrochloride FDA Link 05/2015 - 12/2009
2	Chemokine CXCL12IBA 02/2014 - 11/2003
2	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 01/2013 - 01/2012
2	GTP-Binding Proteins (G-Protein)IBA 04/2011 - 03/2005
2	CXCR4 Receptors (CXCR4 Receptor)IBA 03/2006 - 11/2003
1	CaspasesIBA 09/2023
1	Enoxaparin (Lovenox)FDA LinkGeneric 01/2023
1	Antihypertensive Agents (Antihypertensives)IBA 01/2023
1	Clopidogrel (Plavix)FDA Link 01/2023
1	apixabanIBA 01/2023
1	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA 01/2022

Therapy/Procedure

44	Therapeutics 04/2024 - 03/2004
14	Drug Therapy (Chemotherapy) 01/2021 - 03/2002
3	Immunotherapy 01/2022 - 09/2014
2	Salvage Therapy 01/2021 - 02/2013
2	Aftercare (After-Treatment) 06/2018 - 01/2016
2	Stem Cell Transplantation 05/2017 - 05/2015
2	Radiotherapy 04/2012 - 04/2011
1	Time-to-Treatment 01/2022